Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes

Int J Mol Sci. 2019 Aug 8;20(16):3862. doi: 10.3390/ijms20163862.

Abstract

Astrocytes play vital roles in neurological disorders. The use of human induced pluripotent stem cell (iPSC)-derived astrocytes provides a chance to explore the contributions of astrocytes in human diseases. Here we review human iPSC-based models for neurological disorders associated with human astrocytes and discuss the points of each model.

Keywords: astrocytes; disease modeling; glia; human neurological disorders; iPSC; induced pluripotent stem cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Astrocytes / cytology
  • Astrocytes / metabolism*
  • Biomarkers
  • Cell Differentiation*
  • Disease Susceptibility
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / metabolism
  • Models, Biological*
  • Nervous System Diseases / etiology*
  • Nervous System Diseases / metabolism*
  • Nervous System Diseases / pathology
  • Nervous System Diseases / therapy
  • Neuroglia / cytology
  • Neuroglia / metabolism
  • Phenotype
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / metabolism*

Substances

  • Biomarkers