Manipulation by Methylation: Garnishing mRNAs with m6Am

Katelyn A Doxtader; Yunsun Nam

doi:10.1016/j.molcel.2019.07.019

Manipulation by Methylation: Garnishing mRNAs with m⁶Am

Mol Cell. 2019 Aug 8;75(3):417-418. doi: 10.1016/j.molcel.2019.07.019.

Authors

Katelyn A Doxtader¹, Yunsun Nam²

Affiliations

¹ Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: yunsun.nam@utsouthwestern.edu.

Abstract

In two recent publications in Molecular Cell,Boulias et al. (2019) and Sendinc et al. (2019) use complementary approaches to map m⁶Am modification sites transcriptome-wide and demonstrate that m⁶Am can repress translation while increasing the stability of a subset of low-abundance transcripts.

Publication types

Comment

MeSH terms

Methylation
Protein Processing, Post-Translational*
RNA, Messenger
Transcriptome*

Substances

RNA, Messenger

Grants and funding

R01 GM122960/GM/NIGMS NIH HHS/United States