The single-cell sequencing: new developments and medical applications

Xiaoning Tang; Yongmei Huang; Jinli Lei; Hui Luo; Xiao Zhu

doi:10.1186/s13578-019-0314-y

The single-cell sequencing: new developments and medical applications

Cell Biosci. 2019 Jun 26:9:53. doi: 10.1186/s13578-019-0314-y. eCollection 2019.

Authors

Xiaoning Tang^#^{1

2}, Yongmei Huang^#^{1

2}, Jinli Lei^{1

2}, Hui Luo^{1

2}, Xiao Zhu^{1

2}

Affiliations

¹ 1The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023 China.
² Guangdong Provincial Zhanjiang Bay Key Laboratory, Zhanjiang, 524023 China.

^# Contributed equally.

Abstract

Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and evolutionary relationships of various cells. This review introduces the latest advances in single-cell sequencing technologies and their applications in oncology, microbiology, neurology, reproduction, immunology, digestive and urinary systems, highlighting the important role that single-cell sequencing techniques play in these areas.

Keywords: Cancer; Clinical applications; Developments; Immunology; Single-cell sequencing technologies; Transcriptome.

Publication types

Review