Acyl-CoA-Binding Protein Fuels Gliomagenesis

Junfeng Bi; Paul S Mischel

doi:10.1016/j.cmet.2019.07.007

Acyl-CoA-Binding Protein Fuels Gliomagenesis

Cell Metab. 2019 Aug 6;30(2):229-230. doi: 10.1016/j.cmet.2019.07.007.

Authors

Junfeng Bi¹, Paul S Mischel²

Affiliations

¹ Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
² Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address: pmischel@ucsd.edu.

PMID: 31390546
DOI: 10.1016/j.cmet.2019.07.007

Abstract

Altered lipid metabolism is common in glioblastoma, but its role in tumorigenesis is not well understood. In this issue of Cell Metabolism, Duman et al. (2019) provide new insight into this process, demonstrating that acyl-CoA-binding protein (ACBP) drives glioblastoma growth by promoting mitochondrial long fatty acyl-CoA accumulation and β-oxidation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Acyl Coenzyme A
Carcinogenesis
Carrier Proteins
Diazepam Binding Inhibitor*
Fatty Acids
Glioblastoma*
Humans

Substances

Acyl Coenzyme A
Carrier Proteins
Diazepam Binding Inhibitor
Fatty Acids