How to Untie a Protein Knot

Sitao Yin; Brittiny Dhital; Ya-Ming Hou

doi:10.1016/j.str.2019.07.008

How to Untie a Protein Knot

Structure. 2019 Aug 6;27(8):1190-1191. doi: 10.1016/j.str.2019.07.008.

Authors

Sitao Yin¹, Brittiny Dhital¹, Ya-Ming Hou²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Thomas Jefferson University Philadelphia, PA 19107, USA.
² Department of Biochemistry and Molecular Biology, Thomas Jefferson University Philadelphia, PA 19107, USA. Electronic address: ya-ming.hou@jefferson.edu.

PMID: 31390544
DOI: 10.1016/j.str.2019.07.008

Abstract

The origin of protein backbone threading through a topological knot remains elusive. To understand the evolutionary origin of protein knots, in this issue of StructureKo et al. (2019) used circular permutation to untie a knotted protein. They showed that a domain-swapped dimer releases the knot and the associated high-energy state for substrate binding.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Methyltransferases
Protein Folding*
Proteins
RNA*

Substances

Proteins
RNA
Methyltransferases

Abstract

Publication types

MeSH terms

Substances

Grants and funding