Synthesis of Cyclotriveratrylene-Sucrose-Based Capsules

Łukasz Szyszka; Piotr Cmoch; Aleksandra Butkiewicz; Mykhaylo A Potopnyk; Sławomir Jarosz

doi:10.1021/acs.orglett.9b02451

Synthesis of Cyclotriveratrylene-Sucrose-Based Capsules

Org Lett. 2019 Aug 16;21(16):6523-6528. doi: 10.1021/acs.orglett.9b02451. Epub 2019 Aug 7.

Authors

Łukasz Szyszka¹, Piotr Cmoch¹, Aleksandra Butkiewicz¹, Mykhaylo A Potopnyk¹, Sławomir Jarosz¹

Affiliation

¹ Institute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/52 , 01-224 Warsaw , Poland.

PMID: 31389709
DOI: 10.1021/acs.orglett.9b02451

Abstract

Cyclotriveratrylene (CTV) is a C₃-symmetrical macrocycle, which can be used as a chiral building block in the construction of supramolecular containers. Coupling of the CTV unit with a sucrose molecule gave enantiopure water-soluble (after deprotection) containers. The absolute configuration of the synthesized capsules was determined by NMR and ECD spectroscopies and DFT calculations.

Publication types

Research Support, Non-U.S. Gov't