Associations between methamphetamine use, psychiatric comorbidities and treatment outcome in two inpatient rehabilitation centers

Psychiatry Res. 2019 Oct:280:112505. doi: 10.1016/j.psychres.2019.112505. Epub 2019 Aug 1.

Abstract

The use of methamphetamine is spreading globally and provokes the need for effective treatment options. Previous research showed increased psychiatric comorbidities in methamphetamine users, but its impact on treatment success is still unclear. This study investigates data from two German addiction rehabilitation centers including 108 methamphetamine using individuals. The participants were tested and interviewed at the beginning of the addiction treatment program and at the end of treatment after about six months. In total, 95% of the participants had at least another psychiatric diagnosis. At admission, substance related comorbid diagnoses (meaning abuse or addiction of other substances than methamphetamine) showed a significant effect on treatment dropout. Within the substance related diagnoses, the majority of participants (62%) suffered from cannabinoid dependency. Non-substance related comorbidities and the total number of comorbid diagnoses did not have an impact on treatment outcome. The most frequent non substance specific diagnosis at admission was a depressive disorder (15%). Diagnoses patients had at discharge did not show any effects on the treatment completion. Comparing diagnoses at admission and discharge revealed slight differences, which may rise from a better assessment at discharge due to the fact that clinicians got to know the patients better during the therapeutic process.

Keywords: Addiction; Depression; Dropout; Stimulants; Substance use.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amphetamine-Related Disorders / epidemiology
  • Amphetamine-Related Disorders / psychology*
  • Amphetamine-Related Disorders / therapy*
  • Behavior, Addictive / epidemiology
  • Behavior, Addictive / psychology
  • Behavior, Addictive / therapy
  • Comorbidity
  • Female
  • Hospitalization / trends
  • Humans
  • Inpatients / psychology
  • Male
  • Mental Disorders / epidemiology
  • Mental Disorders / psychology*
  • Mental Disorders / therapy*
  • Methamphetamine / adverse effects*
  • Middle Aged
  • Substance Abuse Treatment Centers / trends*
  • Treatment Outcome

Substances

  • Methamphetamine