TGF-β signaling in cell fate control and cancer

Curr Opin Cell Biol. 2019 Dec:61:56-63. doi: 10.1016/j.ceb.2019.07.007. Epub 2019 Aug 2.

Abstract

Members of the transforming growth factor-β (TGF-β) family regulate cell fate decisions during early embryonic development and tissue homeostasis in the adult. Deregulation of TGF-β family signaling contributes to developmental anomalies, fibrotic disorders, tumorigenesis and immune diseases. TGF-β exerts a wide spectrum of cellular functions by activating canonical (SMAD-dependent) or non-canonical (SMAD-independent) pathways in a cell type-specific and context-dependent manner. Here, we focus on recent advances in the understanding of the mechanisms and functions of SMAD and non-SMAD pathways in physiology and pathology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Lineage / physiology
  • Humans
  • Neoplasms / pathology*
  • Signal Transduction / physiology
  • Smad Proteins / metabolism*
  • Transforming Growth Factor beta / metabolism*

Substances

  • Smad Proteins
  • Transforming Growth Factor beta