Functionally Competent DNA Damage-Free Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair

Circulation. 2019 Aug 6;140(6):520-522. doi: 10.1161/CIRCULATIONAHA.119.040881. Epub 2019 Aug 5.

Authors

Ramaswamy Kannappan¹, James F Turner¹, Jessica M Miller¹, Chengming Fan^{1

2}, Amanda G Rushdi¹, Namakkal Soorappan Rajasekaran^{1

3}, Jianyi Zhang¹

Affiliations

¹ Department of Biomedical Engineering, School of Engineering (R.K., J.F.T., J.M.M., C.F., A.G.R., N.S.R., J.Z.), School of Medicine, The University of Alabama at Birmingham.
² Department of Cardiovascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China (C.F.).
³ Division of Molecular & Cellular Pathology, Department of Pathology (N.S.R.), School of Medicine, The University of Alabama at Birmingham.

No abstract available

Keywords: DNA damage; TP53; cardiac myocytes; pluripotent stem cells.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis
Cell Differentiation
Cell Separation
Coronary Stenosis / therapy
Coronary Vessels
DNA Damage*
Disease Models, Animal
Genes, p53
Graft Survival
Imidazoles / pharmacology
Induced Pluripotent Stem Cells / chemistry
Induced Pluripotent Stem Cells / cytology*
Ligation
Mice
Mice, SCID
Myocytes, Cardiac / cytology
Myocytes, Cardiac / transplantation*
Piperazines / pharmacology

Substances

Imidazoles
Piperazines
nutlin 3

Grants and funding