Small molecule anion transporters display in vitro antimicrobial activity against clinically relevant bacterial strains

Chem Commun (Camb). 2019 Aug 20;55(68):10080-10083. doi: 10.1039/c9cc04304g.

Abstract

Highly active transmembrane anion transporters have demonstrated their activity against antibiotic-resistant and clinically relevant bacterial strains. This type of compound offers promise as a strategy to develop novel antibacterial agents.

MeSH terms

  • Acinetobacter baumannii / drug effects
  • Animals
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Enterococcus faecium / drug effects
  • Erythrocytes / drug effects
  • Hemagglutination / drug effects
  • Hemolysis / drug effects
  • Indoles / chemical synthesis
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Ionophores / chemical synthesis
  • Ionophores / chemistry
  • Ionophores / pharmacology*
  • Klebsiella pneumoniae / drug effects
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa / drug effects
  • Pyrroles / chemical synthesis
  • Pyrroles / chemistry
  • Pyrroles / pharmacology*
  • Rats

Substances

  • Anti-Bacterial Agents
  • Indoles
  • Ionophores
  • Pyrroles