The biological strategies for hearing re-establishment based on the stem/progenitor cells

Mingyu Xia; Jiaoyao Ma; Shan Sun; Wenyan Li; Huawei Li

doi:10.1016/j.neulet.2019.134406

The biological strategies for hearing re-establishment based on the stem/progenitor cells

Neurosci Lett. 2019 Oct 15:711:134406. doi: 10.1016/j.neulet.2019.134406. Epub 2019 Aug 1.

Authors

Mingyu Xia¹, Jiaoyao Ma¹, Shan Sun¹, Wenyan Li², Huawei Li³

Affiliations

¹ ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
² ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: wenyan_li2000@126.com.
³ ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China; Shanghai Engineering Research Centre of Cochlear Implant, Shanghai, 200031, China; The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China. Electronic address: hwli@shmu.edu.cn.

PMID: 31377244
DOI: 10.1016/j.neulet.2019.134406

Abstract

The cochlea is the essential organ for hearing and includes both auditory sensory hair cells and spiral ganglion neurons. The discovery of inner ear stem cell brings hope to the regeneration of hair cell and spiral ganglion neuron as well as the followed hearing re-establishment. Thus the investigation on characteristics of inner ear stem/progenitor cells and related regulating clue is important to make such regeneration a reality. In addition, attempts have also been made to transplant exogenous stem cells into the inner ear to restore hearing function. In this review, we describe recent advances in the characterization of mammalian inner ear progenitor/stem cells and the mechanisms of regulating their proliferation and differentiation, and summarize studies that have used exogenous stem cells to repair damaged hair cells and neurons in the inner ear.

Keywords: Cochlear stem/progenitor cells; Hair cells; Inner ear; Neural stem cells; Spiral ganglion neurons; Supporting cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Ear, Inner*
Hearing*
Humans
Neural Stem Cells*