Precision Medicine for Sleep Loss and Fatigue Management

Luis E Pichard; Guido Simonelli; Lindsay Schwartz; Thomas J Balkin; Steven Hursh

doi:10.1016/j.jsmc.2019.05.006

Precision Medicine for Sleep Loss and Fatigue Management

Sleep Med Clin. 2019 Sep;14(3):399-406. doi: 10.1016/j.jsmc.2019.05.006.

Authors

Luis E Pichard¹, Guido Simonelli², Lindsay Schwartz³, Thomas J Balkin², Steven Hursh³

Affiliations

¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Electronic address: Luis.E.Pichard@gmail.com.
² Behavioral Biology Branch, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
³ Institutes for Behavior Resources, Inc, 2104 Maryland Avenue, Baltimore, MD 21218, USA.

PMID: 31375208
DOI: 10.1016/j.jsmc.2019.05.006

Abstract

Sleep loss is a widespread phenomenon and a public health threat. Sleep disorders, medical conditions, lifestyles, and occupational factors all contribute to insufficient sleep. Regardless of the underlying cause, insufficient sleep has well-defined consequences and the severity of said consequences partially influenced by individual characteristics. It is here where precision medicine needs to understand and define sleep insufficiency in hopes for personalizing medical approach to improve patient outcomes. Following a discussion on causes and consequences of sleep loss, this article discusses tools for assessing sleep sufficiency, mitigating strategies to sleep loss, and sleep loss in the context of fatigue management.

Keywords: Fatigue; Insufficiency; Loss; Management; Modeling; Performance; Sleep.

Publication types

Review

MeSH terms

Fatigue / etiology
Fatigue / therapy*
Humans
Life Style
Precision Medicine*
Sleep
Sleep Deprivation / etiology
Sleep Deprivation / therapy*
Sleep Wake Disorders / complications
Sleep Wake Disorders / therapy