Lower limb exoskeletons (LLEs) are susceptible to falls, and users are at risk of head and/or hip injuries. To address concerns regarding the safety of LLE users, optimization techniques were used to study safe-fall control strategies. Simulation results of these studies showed promising performance that leads to head impact avoidance and mitigation of hip impact velocity. The motivation for the current research was to extend the application of previously developed optimization techniques to study more realistic human-LLE fall conditions. We examined a range of feasible fall durations for the human-LLE model and found the optimal fall duration for which the user's safety is maximized. Next, we used a range of coefficients of friction to examine fall strategies on different ground surface conditions. We found that the effectiveness of a safe-fall strategy is higher when falling on less slippery surfaces compared to more slippery ones. The simulation results were implemented in a half-scale physical model of a three-link inverted pendulum, which represented a human-LLE model. Results of our experiments verified that the optimal safe-fall strategy could be implemented in a mechanical test setup. The hip linear velocity at impact was found to have similar values in both the experimental (2.04 m/s) and simulation results (2.09 m/s). Further studies should be conducted with appropriate software and hardware platforms to successfully implement safe-fall strategies in an actual LLE.