Effects of nanoparticles exposure and PON1 genotype on heart rate variability

Wei-Te Wu; Chung-Ching Wang; Saou-Hsing Liou

doi:10.1016/j.envres.2019.03.015

Effects of nanoparticles exposure and PON1 genotype on heart rate variability

Environ Res. 2019 Sep:176:108377. doi: 10.1016/j.envres.2019.03.015. Epub 2019 Mar 7.

Authors

Wei-Te Wu¹, Chung-Ching Wang², Saou-Hsing Liou³

Affiliations

¹ National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei, Taiwan. Electronic address: ader.una@gmail.com.
² Division of occupational medicine, Division of family medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
³ National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Public Health, National Defense Medical Center, Taipei, Taiwan; Center for Aging and Health, Hualien Tzu Chi Hospital, Hualien, Taiwan. Electronic address: shliou@nhri.org.tw.

PMID: 31374360
DOI: 10.1016/j.envres.2019.03.015

Abstract

Objectives: This study was to assess the association between different NPs exposure and PON1 genotype on Heart Rate Variability (HRV) parameters among workers.

Methods: This study included 235 non-CVD subjects handled to nanomaterials (NM) and 185 non-exposed controls without CVD from 14 NM plants. All participants completed short-term HRV measurements, and were collected blood specimens to measure PON1 activities and the genotype of the PON1 Q192R polymorphism.

Results: In a multivariate regression model, this study observed a positive relationship between nano-Ag exposure and HRV time-domain (RMSSD) and frequency-domain (HF). After adjusting for confounders, the results showed positive associations between RR homozygosity, PON1 paraoxonase/arylesterase activities with HRV, and was particularly noteworthy in RMSSD and HF.

Conclusions: This study shows a significant increment of RMSSD and HF among workers who handled Nano-Ag materials. These results imply that Nano-Ag and PON1 Q192R genotype can trigger ANS reflexes and alter cardiac frequency and function.

Keywords: Heart rate variability; Nanomaterials; Nanoparticles; PON1 Q192R polymorphism; Paraoxonase.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aryldialkylphosphatase / genetics*
Case-Control Studies
Female
Genotype*
Heart Rate*
Humans
Male
Middle Aged
Nanoparticles* / toxicity
Polymorphism, Genetic

Substances

Aryldialkylphosphatase
PON1 protein, human