Data on the sub-chronic toxicity in rats after 30 days of oral realgar administration and the accumulation and distribution of arsenic species

Yan Yi; Shuangrong Gao; Jing Xia; Chunying Li; Yong Zhao; Yushi Zhang; Aihua Liang; Shen Ji

doi:10.1016/j.dib.2018.12.011

Data on the sub-chronic toxicity in rats after 30 days of oral realgar administration and the accumulation and distribution of arsenic species

Data Brief. 2018 Dec 7:23:103572. doi: 10.1016/j.dib.2018.12.011. eCollection 2019 Apr.

Authors

Yan Yi¹, Shuangrong Gao¹, Jing Xia², Chunying Li¹, Yong Zhao¹, Yushi Zhang¹, Aihua Liang¹, Shen Ji²

Affiliations

¹ Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimen Nei, Beijing 100700, China.
² Shanghai Institute for Food and Drug Control, No. 1500 Shanghai Zhang Heng Road, Pudong New District, Shanghai 201203, China.

Abstract

These data are related to the research "The accumulation and distribution of arsenic species and association with arsenic toxicity in rats after 30 days of oral realgar administration" (Yi et al., 2019) [1]. These data include the rat body weights, haematology, electrolytes, coagulation and biochemical parameters, and relative organ weights after 30 days of oral administration of realgar, which was consistent with the current OECD guideline "Repeated Dose 28-Day oral Toxicity Study in Rodents". The data also include the content of arsenite (As(III)), arsenate (As(V)), dimethylarsinic acid (DMA), monomethylarsonic acid (MMAV), arsenic betaine (AsB) and arsenic chrome (AsC) in rat blood, liver, kidneys, brain and urine after single-dose and 30-day oral administration of realgar. The provided data are intended to demonstrate whether realgar has short-term toxicity and the role of accumulated arsenic species in realgar toxicity.