Severe Fever with Thrombocytopenia Syndrome Complicated with Pseudomembranous Aspergillus Tracheobronchitis in a Patient without Apparent Risk Factors for Invasive Aspergillosis

Intern Med. 2019 Dec 15;58(24):3589-3592. doi: 10.2169/internalmedicine.3257-19. Epub 2019 Jul 31.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease. A 91-year-old woman was admitted to our intensive-care unit with SFTS, and she developed dyspnea with wheezes 5 days after admission. Bronchoscopy showed scattered white mold in her central airway. An airway tissue biopsy and culture of bronchial lavage fluid revealed fungal hyphae in the necrotic tissue, confirmed as Aspergillus fumigatus. She was thus diagnosed with pseudomembranous aspergillus tracheobronchitis. She had no common risk factors for invasive aspergillosis (IA). Patients with SFTS, even those without apparent risk factors for IA, may be at risk of developing IA.

Keywords: aspergillus tracheobronchitis; bronchoscopy; invasive aspergillosis; risk factor; severe fever with thrombocytopenia syndrome.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aspergillosis / diagnosis
  • Aspergillosis / etiology*
  • Aspergillus fumigatus / isolation & purification*
  • Biopsy
  • Bronchitis / diagnostic imaging
  • Bronchitis / etiology*
  • Bronchoalveolar Lavage Fluid / microbiology
  • Bronchoscopy
  • Bunyaviridae Infections / complications*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phlebovirus*
  • Risk Factors
  • Thrombocytopenia / complications
  • Tomography, X-Ray Computed
  • Tracheitis / etiology*