Objective: To evaluate the prevalence and risk factors of aortic valve calcification among the elderly (≥65 years old) resident of Wuxi city, Jiangsu province. Methods: The household registration population aged ≥65 years old in Wuxi city was selected as the research subject by stratified sampling method from August 2017 to December 2018. Echocardiography was performed to assess the aortic valve calcification, and the participants were divided into calcification group and non-calcification group. Multivariate logistic regression analysis was used to explore the related risk factors of aortic valve calcification. Results: The age of the respondents was (73.6±7.1) years old, of which 48.8% (461 cases) were males.The prevalence rate of aortic valve calcification was 22.0% (208/944) in the elderly (≥ 65 years old) residents in Wuxi city. The prevalence rate in 65-69 years old, 70-74 years old, 75-79 years old, 80-84 years old and ≥85 years old was 16.7% (58/347),16.7% (41/245),16.2% (26/161),23.3% (24/103), and 67.0% (59/88),respectively. There were significant differences in age, weight, abdominal circumference, hip circumference, high-salt diets, exercise, hypertension, hyperlipidemia, diabetes, coronary heart disease, cerebrovascular disease, and carotid atherosclerosis between the non-calcified group (736 cases) and the calcified group (208 cases) (P<0.01 or 0.05).Multivariate logistic regression analysis showed that age (OR=1.077, 95%CI 1.053-1.101, P<0.001), diabetes mellitus (OR=1.697, 95%CI 1.174-2.453, P=0.005), and coronary heart disease (OR=1.964, 95%CI 1.378-2.799, P<0.001) were the risk factors of aortic valve calcification. Conclusions: The prevalence of aortic valve calcification in the elderly (≥65 years old) residents in Wuxi city of Jiangsu province increases with aging. Age, diabetes mellitus and coronary heart disease are the risk factors of aortic valve calcification in this population cohort.
目的： 调查江苏省无锡市≥65岁老年人主动脉瓣膜钙化的患病率，并探讨其相关危险因素。 方法： 2017年8月至2018年12月，采用分层抽样方法选取年龄≥65岁的江苏省无锡市城区户籍人口作为研究对象。研究对象均行超声心动图检查，根据是否有主动脉瓣膜钙化，将其分为非钙化组和钙化组。通过问卷调查获取该地区老年人主动脉瓣膜钙化的流行病学资料。采用多因素logistic回归分析探讨主动脉瓣膜钙化的危险因素。 结果： 调查对象年龄（73.6±7.1）岁，男性占48.8%（461名）。无锡市≥65岁老年人主动脉瓣膜钙化的患病率为22.0%（208/944），其中65~69、70~74、75~79、80~84和≥85岁人群主动脉瓣膜钙化患病率分别为16.7%（58/347）、16.7%（41/245）、16.2%（26/161）、23.3%（24/103）和67.0%（59/88）。非钙化组（736例）与钙化组（208例）老年人的年龄、体重、腹围、臀围、饮食偏咸、运动、高血压、高脂血症、糖尿病、冠心病、脑血管疾病和颈动脉硬化症差异均有统计学意义（P<0.01或0.05）。多因素logistic回归分析显示，年龄（OR=1.077，95%CI 1.053~1.101，P<0.001）、糖尿病（OR=1.697，95%CI 1.174~2.453，P=0.005）和冠心病（OR=1.964，95%CI 1.378~2.799，P<0.001）是主动脉瓣膜钙化的危险因素。 结论： 江苏省无锡市≥65岁老年人主动脉瓣膜钙化患病率呈现随年龄增大而增高的趋势；年龄、糖尿病和冠心病会增加老年人发生主动脉瓣膜钙化的风险。.
Keywords: Aged; Aortic valve calcification; Prevalence; Risk factors.