Regioselective C-C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C-H activation

Ting Tian; An-Shun Dong; Dan Chen; Xian-Ting Cao; Guannan Wang

doi:10.1039/c9ob01539f

Regioselective C-C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C-H activation

Org Biomol Chem. 2019 Sep 7;17(33):7664-7668. doi: 10.1039/c9ob01539f. Epub 2019 Jul 31.

Authors

Ting Tian¹, An-Shun Dong¹, Dan Chen¹, Xian-Ting Cao¹, Guannan Wang²

Affiliations

¹ The Key Laboratory for Medical Tissue Engineering, College of Medical Engineering, Jining Medical University, P. R. China. chemcxt@mail.jnmc.edu.cn.
² The Key Laboratory for Medical Tissue Engineering, College of Medical Engineering, Jining Medical University, P. R. China. chemcxt@mail.jnmc.edu.cn and Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University), Ministry of Education, 389 Xincun Road, 200065 Shanghai, P. R. China.

PMID: 31365018
DOI: 10.1039/c9ob01539f

Abstract

A regioselective C-C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium catalysis was developed. This transformation tactically linked the 1,2,4-thiadiazoles and succinimides together, and the novel molecules formed may have potential biological activity.

Publication types

Research Support, Non-U.S. Gov't