A highly selective and sensitive 1,8-naphthalimide-based fluorescent sensor for Zn2+ imaging in living cells

Bioorg Med Chem Lett. 2019 Sep 15;29(18):2646-2649. doi: 10.1016/j.bmcl.2019.07.046. Epub 2019 Jul 24.

Abstract

A new 4-amino-1,8-naphthalimide-based fluorescent sensor, with iminoacetic acid and iminoethoxyacetic acid as receptor, was developed. It was applied successfully to detect Zn2+ in aqueous solution and living cells. Under physiological pH conditions, it demonstrates high selectivity and sensitivity for sensing Zn2+ with about 7-fold enhancement in aqueous solution, with a characteristic emission band of 4-amino-1,8-naphthalimide with a green color centered at 550 nm.

Keywords: Fluorescent sensor; Iminoacetic acid; Iminoethoxyacetic acid; Naphthalimide; Zinc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Molecular Structure
  • Naphthalimides / chemical synthesis
  • Naphthalimides / chemistry*
  • Optical Imaging
  • Spectrometry, Fluorescence
  • Zinc / analysis*

Substances

  • Fluorescent Dyes
  • Naphthalimides
  • Zinc