Gene regulation for the extreme resistance to ionizing radiation of Deinococcus radiodurans

Wuzhou Wang; Yun Ma; Junyan He; Huizhou Qi; Fangzhu Xiao; Shuya He

doi:10.1016/j.gene.2019.144008

Gene regulation for the extreme resistance to ionizing radiation of Deinococcus radiodurans

Gene. 2019 Oct 5:715:144008. doi: 10.1016/j.gene.2019.144008. Epub 2019 Jul 27.

Authors

Wuzhou Wang¹, Yun Ma², Junyan He¹, Huizhou Qi³, Fangzhu Xiao⁴, Shuya He⁵

Affiliations

¹ Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang 421001, China; Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang 421001, China.
² Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang 421001, China.
³ Function Laboratory Center, Hengyang Medical College, University of South China, Hengyang 421001, China; Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang 421001, China.
⁴ Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang 421001, China.
⁵ Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang 421001, China; Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang 421001, China. Electronic address: heshuya8502@163.com.

PMID: 31362038
DOI: 10.1016/j.gene.2019.144008

Abstract

Deinococcus radiodurans is a model microorganism used for studies on DNA repair and antioxidation due to its extraordinary tolerance to ionizing radiation and other DNA-damaging agents. Various transcriptome analyses have revealed that hundreds of genes are induced and that many other genes are repressed during recovery of D. radiodurans following irradiation, suggesting that gene regulation is of great importance for the extreme resistance of this microorganism to ionizing radiation. In this article, we focus on some reported strategies that are employed by D. radiodurans to regulate the genes implicated in its extreme tolerance to ionizing radiation for a comprehensive understanding of the reasons this bacterium can survive such extraordinary stress. We expect this review to shed light on potential radioprotective agents and applications for use in a range of fields.

Keywords: Deinococcus radiodurans; RDRM; Radioresistance; Two-component systems; sRNA.

Publication types

Review

MeSH terms

Bacterial Proteins / genetics
Bacterial Proteins / metabolism
DNA Damage
DNA Repair / radiation effects*
DNA, Bacterial / genetics
DNA, Bacterial / metabolism*
Deinococcus / genetics
Deinococcus / metabolism*
Gene Expression Regulation, Bacterial / radiation effects*
Radiation Tolerance*
Radiation, Ionizing*

Substances

Bacterial Proteins
DNA, Bacterial