Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma

Jinhong Park; Hyun Jae Lee; Doona Song; Mia Gi; Sungwoo Jo; Dong-Kyu Jeon; Yohan Seo; Bomin Kim; Ho Lee; Wan Namkung; Gyoonhee Han; Jae Young Choi

doi:10.1016/j.jaci.2019.07.016

Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma

J Allergy Clin Immunol. 2019 Nov;144(5):1425-1428.e12. doi: 10.1016/j.jaci.2019.07.016. Epub 2019 Jul 27.

Authors

Jinhong Park¹, Hyun Jae Lee², Doona Song³, Mia Gi², Sungwoo Jo⁴, Dong-Kyu Jeon⁴, Yohan Seo⁴, Bomin Kim⁵, Ho Lee⁶, Wan Namkung⁷, Gyoonhee Han⁸, Jae Young Choi⁹

Affiliations

¹ College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea; Department of Integrated OMICS for Biomedical Science, Yonsei University, Seoul, Korea.
² Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
³ Translational Research Center for Protein Function Control, Department of Biotechnology, Yonsei University, Seoul, Korea.
⁴ College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea.
⁵ Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
⁶ Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Korea.
⁷ College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea; Department of Integrated OMICS for Biomedical Science, Yonsei University, Seoul, Korea. Electronic address: wnamkung@yonsei.ac.kr.
⁸ College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea; Department of Integrated OMICS for Biomedical Science, Yonsei University, Seoul, Korea; Translational Research Center for Protein Function Control, Department of Biotechnology, Yonsei University, Seoul, Korea. Electronic address: gyoonhee@yonsei.ac.kr.
⁹ Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea. Electronic address: jychoi@yuhs.ac.

PMID: 31362010
DOI: 10.1016/j.jaci.2019.07.016

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Asthma / drug therapy*
Disease Models, Animal
Dual Oxidases / genetics
Dual Oxidases / metabolism
Eosinophils / immunology*
Gene Expression Regulation
Goblet Cells / pathology
Humans
Hyperplasia
Mice
Mucin 5AC / genetics
Mucin 5AC / metabolism
Mucins / genetics
Mucins / metabolism*
NIH 3T3 Cells
Nasal Mucosa / drug effects
Nasal Mucosa / physiology*
Neutrophils / immunology*
Oxazoles / chemistry
Oxazoles / therapeutic use*
Respiratory Hypersensitivity / drug therapy*
Sulfate Transporters / antagonists & inhibitors

Substances

Muc5ac protein, mouse
Mucin 5AC
Mucins
Oxazoles
Slc26a4 protein, mouse
Sulfate Transporters
YS-01
Dual Oxidases
Duox1 protein, mouse