Structural Characterization of a Gold/Serum Albumin Complex

Alessandro Pratesi; Damiano Cirri; Dolores Fregona; Giarita Ferraro; Anna Giorgio; Antonello Merlino; Luigi Messori

doi:10.1021/acs.inorgchem.9b01900

Structural Characterization of a Gold/Serum Albumin Complex

Inorg Chem. 2019 Aug 19;58(16):10616-10619. doi: 10.1021/acs.inorgchem.9b01900. Epub 2019 Jul 30.

Authors

Alessandro Pratesi¹, Damiano Cirri¹, Dolores Fregona², Giarita Ferraro³, Anna Giorgio³, Antonello Merlino³, Luigi Messori¹

Affiliations

¹ Laboratory of Metals in Medicine (MetMed), Department of Chemistry "U. Schiff" , University of Florence , via della Lastruccia 3 , 50019 Sesto Fiorentino , Italy.
² Department of Chemical Sciences , University of Padova , via Marzolo 1 , 35131 Padova , Italy.
³ Department of Chemical Sciences , University of Naples Federico II , via Cinthia , 80126 Napoli , Italy.

PMID: 31361466
DOI: 10.1021/acs.inorgchem.9b01900

Abstract

The medicinal gold(III) dithiocarbamato complex AuL₁₂ forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin.