First Clinical Case of In Vivo Acquisition of DHA-1 Plasmid-Mediated AmpC in a Salmonella enterica subsp. enterica Isolate

Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00992-19. doi: 10.1128/AAC.00992-19. Print 2019 Oct.

Abstract

A pan-susceptible Salmonella enterica serovar Worthington isolate was detected in the stool of a man returning from Sri Lanka. Under ceftriaxone treatment, a third-generation cephalosporin (3GC)-resistant Salmonella Worthington was isolated after 8 days. Molecular analyses indicated that the two isolates were identical. However, the latter strain acquired a blaDHA-1-carrying IncFII plasmid probably from a Citrobacter amalonaticus isolate colonizing the gut. This is the first report of in vivo acquisition of plasmid-mediated resistance to 3GCs in S. enterica.

Keywords: AmpC; DHA; Worthington; gut; plasmid-mediated resistance; treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cephalosporin Resistance / genetics
  • Cephalosporins / pharmacology*
  • Citrobacter / drug effects
  • Citrobacter / genetics
  • Drug Resistance, Multiple, Bacterial / genetics
  • Microbial Sensitivity Tests
  • Plasmids / genetics*
  • Salmonella / drug effects*
  • Salmonella / genetics*

Substances

  • Cephalosporins

Supplementary concepts

  • Citrobacter amalonaticus
  • Salmonella enterica subsp. enterica