Cylindromatosis gene is a kind of tumor suppressor genes, whose mutation or deletion will lead to the development of a cylindrical tumor. The deubiquitinating enzyme CYLD protein encoded by it is a member of the deubiquitinating enzyme family. CYLD alters the function of the target molecules by removing the ubiquitin chain linked to the substrate protein K63, and participates in the regulation of signaling pathways, such as NF-κB, JNK and Wnt. This article reviews the recent year's research progress of CYLD, especially its negative regulatory role in the progression of liver-related diseases.
圆柱瘤基因（CYLD）是一种肿瘤抑制基因，其突变或缺失将会导致圆柱瘤的发生。由其编码的去泛素化酶CYLD蛋白是去泛素化酶家族的成员。CYLD通过移除底物蛋白K63连接的泛素链来改变靶分子的功能，并参与核因子κB、JNK和Wnt等信号通路的调控。现就近年CYLD的研究进展，尤其在肝脏相关疾病进展中的负向调控作用进行综述。.
Keywords: Deubiquitinating enzyme; Gene, cylindromatosis; Liver disease; Ubiquitination.