Association between F+1 polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene and chronic obstructive pulmonary disease susceptibility: An evidence-based meta-analysis

Abstract

Background: The F+1 (rs511898 G>A) polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene has been implicated in susceptibility of chronic obstruction pulmonary disease (COPD). However, a series of studies have reported inconclusive. The aim of this study is to explore the association between the F+1 (rs511898) of ADAM33 gene and COPD susceptibility by using the method of meta-analysis.

Method: PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure database (CNKI), Chongqing VIP database, Wanfang and China Biology Medicine (CBM) were searched comprehensively to obtain the related cohort studies and case-control studies. The included studies were selected according to inclusion criteria. The pooled odds ratios were performed respectively for allele comparison, additive model, dominant genetic model and recessive genetic model. The association between the F+1 polymorphism of ADAM33 gene and COPD susceptibility was measured by OR and 95%CI by STATA 12.0. The subgroup analysis was distinguished according to the ethnicity. The publication bias was tested by funnel plots and Egger's linear regression method.

Results: Twelve case-control studies were included in the meta-analysis, which study is comprised of 6935 participants (2454 patients with COPD and 4481 controls). The meta results showed significant association between ADAM33 F+1 polymorphism and COPD susceptibility in allele model OR _total = 1.16(95% CI 1.04-1.30, P = 0.007), OR _Asian = 1.14(95% CI 1.02-1.27, P = 0.022), additive model OR _total = 1.27 (95% CI 1.13-1.43, P = 0.000), OR _Asian = 1.25 (95% CI 1.08-1.45, P = 0.003), recessive model OR _total = 1.49 (95% CI 1.16-1.91, P = 0.002), OR _Asian = 1.56(95% CI 1.09-2.22, P = 0.014), but not significant in Caucasians.

Conclusion: The ADAM33 F+1 mutant gene A may increase the risk of COPD among the Asian population, while it may not associate with the European population.

Keywords: A disintegrin and metalloprotease 33; Chronic obstructive pulmonary disease; Meta-analysis; Polymorphism; rs511898.