Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

Xuehui Fan; Tianyi Sun; William Crawford; Xiaoqiu Tan; Xianhong Ou; Derek A Terrar; Steven N Ebert; Ming Lei

doi:10.3389/fphys.2019.00713

Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

Front Physiol. 2019 Jul 10:10:713. doi: 10.3389/fphys.2019.00713. eCollection 2019.

Authors

Xuehui Fan¹, Tianyi Sun², William Crawford², Xiaoqiu Tan¹, Xianhong Ou¹, Derek A Terrar², Steven N Ebert³, Ming Lei^{1

2}

Affiliations

¹ Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
² Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
³ Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, United States.

Abstract

In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca²⁺ transient properties, and potential role in localized adrenergic signaling are discussed.

Keywords: Pnmt; Pnmt-derived cardiomyocytes; catecholamines; heart; optogenetics.

Publication types

Review

Abstract

Publication types

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