Abstract
Excessive accumulation of reducing agents in the ER leads to a constitutively high UPR. And the co-function of GSH, Cys and HOCl in biological processes is not well understood. To address this, a TP probe, NPCC, was developed for monitoring reductive stress in the ER. It can also distinguish cancer cells from normal cells.
MeSH terms
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Animals
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Coumarins / chemical synthesis
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Coumarins / chemistry*
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Cysteine / chemistry
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Cysteine / metabolism
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Endoplasmic Reticulum / metabolism*
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Endoplasmic Reticulum Stress / physiology*
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Glutathione / chemistry
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Glutathione / metabolism
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Goats
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HeLa Cells
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Humans
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Hypochlorous Acid / chemistry
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Hypochlorous Acid / metabolism
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Mice
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Microscopy, Confocal / methods
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Microscopy, Fluorescence / methods
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Oxidation-Reduction
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry*
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Zebrafish
Substances
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Coumarins
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Fluorescent Dyes
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Pyrazoles
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Hypochlorous Acid
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Glutathione
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Cysteine