Ocular Co-Morbidities of Atopic Dermatitis. Part II: Ocular Disease Secondary to Treatments

Am J Clin Dermatol. 2019 Dec;20(6):807-815. doi: 10.1007/s40257-019-00465-3.

Abstract

Treatments used for managing atopic dermatitis (AD) may have adverse ocular effects that permanently affect vision. The objective of this review is to raise awareness among dermatologists regarding the potential ocular adverse effects of various AD therapies, including corticosteroids, calcineurin inhibitors, an interleukin-4 receptor α (IL-4Rα) antagonist, and phototherapy. Pertinent potential short- and long-term risks of these therapies include elevations in intraocular pressure from use of topical corticosteroids and conjunctivitis from use of dupilumab. Since some of these adverse effects may not exhibit symptomatology until permanent vision impairment occurs, it is important for dermatologists to understand these risks and proactively ensure their patients are receiving appropriate measures to prevent them.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / adverse effects
  • Antibodies, Monoclonal, Humanized / adverse effects
  • Calcineurin Inhibitors / adverse effects
  • Dermatitis, Atopic / therapy*
  • Dermatologic Agents / adverse effects*
  • Eye Diseases / epidemiology
  • Eye Diseases / etiology*
  • Eye Diseases / prevention & control
  • Humans
  • Intraocular Pressure / drug effects
  • Phototherapy / adverse effects*
  • Phototherapy / methods

Substances

  • Adrenal Cortex Hormones
  • Antibodies, Monoclonal, Humanized
  • Calcineurin Inhibitors
  • Dermatologic Agents
  • dupilumab