Magnetic nanorods for remote disruption of lipid membranes by non-heating low frequency magnetic field

Irina M Le-Deygen; Kseniya Yu Vlasova; Ekaterina O Kutsenok; Azizbek D Usvaliev; Maria V Efremova; Alexander O Zhigachev; Polina G Rudakovskaya; Dmitry Yu Golovin; Sergey L Gribanovsky; Elena V Kudryashova; Alexander G Majouga; Yury I Golovin; Alexander V Kabanov; Natalia L Klyachko

doi:10.1016/j.nano.2019.102065

Magnetic nanorods for remote disruption of lipid membranes by non-heating low frequency magnetic field

Nanomedicine. 2019 Oct:21:102065. doi: 10.1016/j.nano.2019.102065. Epub 2019 Jul 23.

Authors

Affiliations

¹ Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, Russia.
² Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, Russia; National University of Science and Technology "MISIS" (MISIS), Moscow, Russia.
³ G.R. Derzhavin Tambov State University, Tambov, Russia.
⁴ National University of Science and Technology "MISIS" (MISIS), Moscow, Russia; Mendeleev University of Chemical Technology of Russia, Moscow, Russia.
⁵ Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, Russia; G.R. Derzhavin Tambov State University, Tambov, Russia.
⁶ Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, Russia; University of North Carolina at Chapel Hill, NC, USA. Electronic address: kabanov@email.unc.edu.
⁷ Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, Russia; G.R. Derzhavin Tambov State University, Tambov, Russia; University of North Carolina at Chapel Hill, NC, USA. Electronic address: klyachko@enzyme.chem.msu.ru.

PMID: 31349089
DOI: 10.1016/j.nano.2019.102065

Abstract

This work presents direct evidence of disordering of liposomal membranes by magnetic nanoparticles during their exposures to non-heating alternating Extremely Low Frequency Magnetic Field (ELF MF). Changes in the lipid membrane structure were demonstrated by the Attenuated total reflection Fourier Transform Infrared and fluorescence spectroscopy. Specifically, about 50% of hydrophobic chains became highly mobile under the action of ELF MF. Magnetic field-induced increase in the membrane fluidity was accompanied by an increase in membrane permeability and release of solutes entrapped in liposomes. The effect of ELF MF on the membrane fluidity was greater in case of 70 × 12 nm magnetite nanorods adsorbed on the liposomes surface compared to liposomes with ~7 nm spherical MNPs embedded within lipid membranes. A physical model of this process explaining experimental data is suggested. The obtained results open new horizons for the development of systems for triggered drug release without dangerous heating and overheating of tissues.

Keywords: ATR-FTIR spectroscopy; Extremely low frequency magnetic field (ELF MF); Liposome; Magnetic nanoparticles; Remote control.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Liposomes
Magnetic Fields*
Membrane Fluidity
Models, Chemical*
Nanotubes / chemistry*
Permeability

Substances

Liposomes