Mitochondrial-associated protein biomarkers in patients with attention-deficit/hyperactivity disorder

Mitochondrion. 2019 Nov:49:83-88. doi: 10.1016/j.mito.2019.07.007. Epub 2019 Jul 23.

Abstract

This study aimed to determine the role of mitochondria-associated proteins (HtrA2, α-synuclein, and Park7) in attention deficit/hyperactivity disorder (ADHD). A total of 125 patients with ADHD (77.6% were males) and 66 healthy controls (66.7% were males) were recruited. We found that girls with ADHD demonstrated higher plasma HtrA2 level than control girls, and their HtrA2 levels were positively correlated with verbal comprehensive ability, and negatively correlated to behavior symptoms. Among boys, we observed no correlations between these mitochondrial proteins, neuropsychological findings, and clinical symptoms. Our findings suggest that an underlying gender-specific mitochondria pathway may influence with the pathophysiology of ADHD.

Keywords: ADHD; Biomarkers; Dopamine; Mitochondrion; Protein.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Attention Deficit Disorder with Hyperactivity / metabolism*
  • Attention Deficit Disorder with Hyperactivity / pathology
  • Biomarkers / metabolism
  • Child
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Mitochondria / metabolism*
  • Mitochondria / pathology
  • Mitochondrial Proteins / metabolism*
  • Sex Characteristics*

Substances

  • Biomarkers
  • Mitochondrial Proteins