MCCB cognitive profile in Spanish first episode schizophrenia patients

R Rodriguez-Jimenez; J L Santos; M Dompablo; J Santabárbara; A I Aparicio; R Olmos; E Jiménez-López; E Sánchez-Morla; A Lobo; T Palomo; R S Kern; M F Green; K H Nuechterlein; L García-Fernández

doi:10.1016/j.schres.2019.07.011

MCCB cognitive profile in Spanish first episode schizophrenia patients

Schizophr Res. 2019 Sep:211:88-92. doi: 10.1016/j.schres.2019.07.011. Epub 2019 Jul 22.

Authors

R Rodriguez-Jimenez¹, J L Santos², M Dompablo³, J Santabárbara⁴, A I Aparicio², R Olmos⁵, E Jiménez-López⁶, E Sánchez-Morla⁷, A Lobo⁸, T Palomo⁹, R S Kern¹⁰, M F Green¹⁰, K H Nuechterlein¹¹, L García-Fernández¹²

Affiliations

¹ Department of Psychiatry, Instituto de Investigación Sanitaria Hospital, 12 de Octubre (imas12), Madrid, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Facultad de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain. Electronic address: roberto.rodriguez.jimenez@gmail.com.
² CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Department of Psychiatry, Hospital Virgen de La Luz, Cuenca, Spain.
³ Department of Psychiatry, Instituto de Investigación Sanitaria Hospital, 12 de Octubre (imas12), Madrid, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain.
⁴ CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Department of Preventive Medicine and Public Health, Universidad de Zaragoza, Spain.
⁵ Department of Psychiatry, Instituto de Investigación Sanitaria Hospital, 12 de Octubre (imas12), Madrid, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Department Social Psychology and Methodology, UAM, Madrid, Spain.
⁶ CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain.
⁷ Department of Psychiatry, Instituto de Investigación Sanitaria Hospital, 12 de Octubre (imas12), Madrid, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Facultad de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain.
⁸ CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Department of Psychiatry, Universidad de Zaragoza, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Spain.
⁹ CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Facultad de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain.
¹⁰ Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, USA; VA Greater Los Angeles Healthcare System, Los Angeles, USA.
¹¹ Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, USA; Department of Psychology, UCLA, Los Angeles, USA.
¹² CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Department of Psychiatry, Hospital San Juan, Alicante, Spain.

PMID: 31345706
DOI: 10.1016/j.schres.2019.07.011

Abstract

The objective of the study was to examine the cognitive profile of Spanish patients with a first episode of schizophrenia (FESz) and to compare that to the profile of patients with a chronic schizophrenia (CSz) and non-psychiatric (NP) control subjects. The study included 106 FESz, 293 CSz, and 210 NP, assessed with the Spanish version of the MATRICS Consensus Cognitive Battery (MCCB). The MCCB cognitive profile in a Spanish sample of FESz was similar to the cognitive profile of CSz with some discrepancies in select domains. The scores of both patient samples were about 1-2 SD below the scores of non-psychiatric control subjects.

Keywords: Cognition; First episode; MATRICS; MCCB; Schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Adult
Case-Control Studies
Chronic Disease
Cognition
Cognitive Dysfunction / physiopathology*
Cognitive Dysfunction / psychology
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Schizophrenia / physiopathology*
Schizophrenic Psychology*
Spain
Young Adult