Meta-analysis of Oxygenation Saturation Targeting Trials: Do Infant Subgroups Matter?

Clin Perinatol. 2019 Sep;46(3):579-591. doi: 10.1016/j.clp.2019.05.003. Epub 2019 Jun 10.

Abstract

Participant data from approximately 5000 infants have been meta-analyzed to guide oxygen saturation policy for extremely preterm infants. The Neonatal Oxygenation Prospective Meta-analysis showed that targeting a higher oxygen saturation range compared with a lower range resulted in decreased death and necrotizing enterocolitis and no difference in major disability but increased treated retinopathy of prematurity (ROP) and supplemental oxygen use at 36 weeks' postmenstrual age. The 91% to 95% range can be recommended for all extremely preterm infants from birth but should be accompanied by stringent surveillance for the prevention and early treatment of ROP.

Keywords: Extremely preterm infants; Oxygen saturation targeting; Prospective meta-analysis; Subgroup analysis.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Humans
  • Infant, Extremely Premature*
  • Infant, Newborn
  • Infant, Premature, Diseases / metabolism*
  • Infant, Premature, Diseases / therapy
  • Oximetry
  • Oxygen / metabolism*
  • Oxygen Consumption / physiology*
  • Oxygen Inhalation Therapy / methods*
  • Randomized Controlled Trials as Topic

Substances

  • Oxygen