Pituitary Tumors in Pregnancy

Wenyu Huang; Mark E Molitch

doi:10.1016/j.ecl.2019.05.004

Pituitary Tumors in Pregnancy

Endocrinol Metab Clin North Am. 2019 Sep;48(3):569-581. doi: 10.1016/j.ecl.2019.05.004. Epub 2019 Jun 13.

Authors

Wenyu Huang¹, Mark E Molitch²

Affiliations

¹ Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue, Suite 530, Chicago, IL 60611, USA.
² Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue, Suite 530, Chicago, IL 60611, USA. Electronic address: molitch@northwestern.edu.

PMID: 31345524
DOI: 10.1016/j.ecl.2019.05.004

Abstract

Pituitary adenomas are common. The impact of pituitary tumors on fertility are mainly caused by oversecretion and/or undersecretion of pituitary hormones or compression of pituitary stalk and normal pituitary tissue by the tumor. Diagnosing and managing pituitary tumors during pregnancy involve many challenges, including the effect of hormone excess or deficiency on pregnancy outcome, changes in the pituitary or pituitary-related hormones, changes in tumor size, and the impact of various treatments of pituitary tumors on maternal and fetal outcomes. This article discusses the diagnosis and treatment of patients with prolactinomas, acromegaly, Cushing disease, and other pituitary tumors during pregnancy.

Keywords: Acromegaly; Cushing disease; Pituitary tumor; Pregnancy; Prolactinoma.

Publication types

Review

MeSH terms

Acromegaly / diagnosis
Acromegaly / epidemiology
Acromegaly / etiology
Acromegaly / therapy
Female
Humans
Pituitary Neoplasms / complications
Pituitary Neoplasms / diagnosis*
Pituitary Neoplasms / epidemiology
Pituitary Neoplasms / therapy*
Pregnancy
Prolactinoma / complications
Prolactinoma / diagnosis*
Prolactinoma / epidemiology
Prolactinoma / therapy*