A selective thioxothiazolidin-coumarin probe for Hg2+ based on its desulfurization reaction. Exploring its potential for live cell imaging

Abstract

Sensing the most toxic heavy metal (mercury) has attracted a lot of attention in recent years due to its extreme harmfulness to both human health and the environment. Thus, we reported herein the synthesis, spectroscopic and kinetic characterization, and biological evaluation of a new thioxothiazolidin coumarin derivative (ILA92), which undergoes a desulfurization reaction induced by mercuric ions (Hg²⁺). This process is the origin of a selective sensing of Hg²⁺ ions in aqueous solution by colorimetric and fluorescent methods. Furthermore, the probe showed great potential for imaging Hg²⁺ in living cells.

Keywords: Colorimetric fluorescent dye; Desulfurization reaction; Hg(2+) ions; Naked eye sensor; Thioxothiazolidin coumarin derivative.