Palladium-Catalyzed C-H Diarylation of Ferrocenecarboxylic Acids with Aryl Iodides

J Org Chem. 2019 Oct 18;84(20):13144-13149. doi: 10.1021/acs.joc.9b01503. Epub 2019 Aug 7.

Abstract

Palladium-catalyzed C-H diarylation of ferrocenes is described. In the presence of 10 mol % Pd(OAc)2, direct C-H diarylation reactions of commercially available ferrocenecarboxylic acid with aryl iodides proceeded smoothly to afford diarylated ferrocenes bearing a variety of functional groups in moderate to good yields. The carboxylic group could also act as a remote directing group to result in the third arylation on the other Cp ring of ferrocene.

Publication types

  • Research Support, Non-U.S. Gov't