An anti-inflammatory nanoagent for tumor-targeted photothermal therapy

Chem Commun (Camb). 2019 Aug 21;55(65):9645-9648. doi: 10.1039/c9cc04486h. Epub 2019 Jul 24.

Abstract

We developed an anti-inflammatory nanoagent by combining polydopamine nanospheres with aspirin and cancer cell membrane coating, which can effectively kill cancer cells and simultaneously eliminate photothermal therapy-induced inflammation.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / toxicity
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / toxicity
  • Apoptosis / radiation effects
  • Aspirin / pharmacology*
  • Aspirin / toxicity
  • Cell Line, Tumor
  • Cell Membrane / chemistry
  • Combined Modality Therapy / methods
  • Drug Carriers / chemistry*
  • Drug Carriers / toxicity
  • Drug Screening Assays, Antitumor
  • Female
  • Hyperthermia, Induced / methods
  • Indoles / chemical synthesis
  • Indoles / chemistry*
  • Indoles / radiation effects
  • Indoles / toxicity
  • Infrared Rays
  • Mammary Neoplasms, Experimental / therapy
  • Mice, Inbred BALB C
  • Nanospheres / chemistry*
  • Nanospheres / radiation effects
  • Nanospheres / toxicity
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Polymers / radiation effects
  • Polymers / toxicity

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Drug Carriers
  • Indoles
  • Polymers
  • polydopamine
  • Aspirin