Data on cytotoxic pattern of cholesterol analogs for lung adenocarcinoma cells

Yamixa Delgado; Anamaris Torres; Melissa Milian

doi:10.1016/j.dib.2019.104179

Data on cytotoxic pattern of cholesterol analogs for lung adenocarcinoma cells

Data Brief. 2019 Jun 25:25:104179. doi: 10.1016/j.dib.2019.104179. eCollection 2019 Aug.

Authors

Yamixa Delgado¹, Anamaris Torres¹, Melissa Milian¹

Affiliation

¹ Laboratory of Drug Design & Delivery, Biochemistry and Pharmacology Department, San Juan Bautista School of Medicine, USA.

Abstract

Cholesterol (Cho) is a sterol that plays an essential role in the maintenance of biologic cell membranes, and various lipoproteins are its carriers through blood circulation [1]. Some FDA-approved anticancer drugs (i.e., Lipoplatin and Myocet) are conjugated to Cho moieties to improve their pharmacokinetic properties, cellular uptake and target specificity [2]. Recently natural and synthetic sterol compounds have shown a broad spectrum of pharmacological activities [3,4]. Herein, we investigated the anticancer activity of various natural Cho analogs, ie. asiatic acid (AsA), betulinic acid (BeA), oleanolic acid (OleA), ursolic Acid (UrA), lupeol (Lupe) and β-sitosterol (β-Sito) against non-small cell lung adenocarcinoma (A549). We performed theoretical calculations of the biophysicochemical properties, and viability assays in a range of 5-100 μM in A549 cells of these Cho analogs. We used ChemSketch and ChemSpider to determine physical properties, and GraphPad Prism 8 software for the data analysis to determine the inhibitory concentrations at 50% (IC₅₀) of each compound.