Genetic variants of DNA repair pathway genes on lung cancer risk

Wanzhen Li; Meng Zhang; Caojuan Huang; Jalin Meng; Xingxu Yin; Gengyun Sun

doi:10.1016/j.prp.2019.152548

Genetic variants of DNA repair pathway genes on lung cancer risk

Pathol Res Pract. 2019 Oct;215(10):152548. doi: 10.1016/j.prp.2019.152548. Epub 2019 Jul 18.

Authors

Wanzhen Li¹, Meng Zhang¹, Caojuan Huang¹, Jalin Meng¹, Xingxu Yin¹, Gengyun Sun²

Affiliations

¹ Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Institute of Respiratory department, Anhui Medical University, Hefei, China; Graduate School of Anhui Medical University, Hefei, China.
² Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Institute of Respiratory department, Anhui Medical University, Hefei, China; Graduate School of Anhui Medical University, Hefei, China. Electronic address: sungengy@126.com.

PMID: 31337555
DOI: 10.1016/j.prp.2019.152548

Abstract

As is commonly perceived, polymorphisms in genes of deoxyribonucleic acid (DNA) repair pathway plays a fundamental role in defective DNA repair and mutagenesis prevention and serves to contribute to the individual susceptibility to the development of a variety of cancers. Recently, an increasing number of studies have been dedicated to the contentious and ambiguous links between polymorphisms in genes of DNA repair pathway and lung cancer (LC) risk. In response, a comprehensive updated meta-analysis has been proposed herein to assess the correlation between polymorphisms of DNA repair pathway genes and susceptibility to LC. This paper has identified and retrieved eligible articles from PubMed, Google Scholar, Web of Science, and CNKI databases till February 20, 2019. Finally, 295 case-control studies as to the fourteen polymorphisms of DNA repair pathway genes were enrolled. When the results have been pooled, we have brought to light the conclusion that ERCC2-rs13181 polymorphism has an elevated association with LC risk under allele, heterozygote, and dominant comparisons. In the subgroup analysis by ethnicity, we have found that the Caucasian individuals with "B" variant possess risk of LC which was more than twice as much as allele, homozygote, and recessive models. In comparison, Asian carriers of rs13181 polymorphism in ERCC2 gene are more susceptible to LC in heterozygote, dominant models. To sum up, ERCC2-rs13181 polymorphism could be a critical factor in stimulating LC evolvement. Future studies with a larger sample size and multivariate factors are needed to vindicate these findings.

Keywords: DNA repair pathway genes; Lung cancer; Meta-Analysis; Polymorphism; Risk.

Publication types

Review

MeSH terms

Alleles
DNA Repair / genetics*
Genetic Predisposition to Disease*
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / pathology
Polymorphism, Single Nucleotide*
Xeroderma Pigmentosum Group D Protein / genetics*

Substances

Xeroderma Pigmentosum Group D Protein
ERCC2 protein, human