Cardiac Changes in Patients on Long-Term Parenteral Nutrition

Nutrients. 2019 Jul 13;11(7):1587. doi: 10.3390/nu11071587.

Abstract

Patients with short bowel syndrome (SBS) on long-term home parenteral nutrition (HPN) chronically receive high fluid volumes directly into the right atrium (RA) through the superior vena cava. We retrospectively evaluated cardiac function measured by routine transthoracic echocardiography (TTE) in a population of 26 SBS patients on long-term HPN and compared their data on echocardiograph-derived right heart structure and function, with those of a control group of 26 patients also bearing a central venous catheter (CVC) for other reasons. Results showed that body weight and BMI were significantly higher in the control group. The echocardiographic estimate of RA pressure was higher in HPN patients than in controls (p = 0.01). An increased estimate of RA pressure indicates the need to consider TTE in the follow-up of long-term HPN patients to detect functional impairment early.

Keywords: cardiac changes; home parenteral nutrition; short bowel syndrome; transthoracic echocardiography.

MeSH terms

  • Adult
  • Aged
  • Central Venous Catheters
  • Female
  • Heart / drug effects*
  • Hemodynamics / drug effects*
  • Humans
  • Male
  • Middle Aged
  • Parenteral Nutrition / adverse effects*
  • Retrospective Studies
  • Short Bowel Syndrome / diet therapy
  • Vena Cava, Inferior / drug effects*
  • Young Adult