Promethazine

Excerpt

Promethazine is a medication used to manage and treat allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine also has off-label uses for nausea and vomiting in pregnancy. Promethazine is a phenothiazine derivative with antidopaminergic, antihistamine, and anticholinergic properties. Promethazine is a phenothiazine derivative with antidopaminergic, antihistamine, and anticholinergic properties. Other phenothiazine derivatives include prochlorperazine and chlorpromazine. Promethazine works as a direct antagonist at the mesolimbic dopamine receptors and alpha-adrenergic receptors in the brain. Promethazine exhibits its antihistamine effects as an H1-receptor blocker. This activity reviews the FDA approved-indications, mechanism of action, administration, dosing, adverse drug reactions, contraindications, warning, precautions, monitoring, and toxicity of promethazine. In addition, this activity will highlight the pertinent interprofessional roles of the interprofessional team during the use of promethazine n the treatment of patients with allergic conditions, nausea and vomiting, motion sickness, and related conditions.