Blood cell development begins as early as the seventh day of embryonic life. Red blood cells are essential in delivering oxygen to tissues and the development of vascular channels during embryogenesis. The ontogeny and maturation of these blood cell lineages is a complex process that involves two critical developmental steps: the production of primitive erythroid cells (EryP) followed by an expanding population of definitive erythroid cells (EryD) that predominate subsequently. Failure of primitive erythropoiesis in toto can prove fatal to the embryo.
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