Epitope-imprinted mesoporous silica nanoparticles for specific recognition of tyrosine phosphorylation

Chem Commun (Camb). 2019 Aug 15;55(67):9927-9930. doi: 10.1039/c9cc03950c.

Abstract

Tyrosine phosphorylation regulates the upstream signaling pathway but accounts for less than 0.1% of total phosphorylation in human cells. Herein, molecularly imprinted mesoporous materials were first synthesized to recognize the phosphorylated tyrosine residue from other phosphorylated residues.

MeSH terms

  • Adsorption
  • Epitopes*
  • Kinetics
  • Molecular Imprinting*
  • Nanoparticles / chemistry*
  • Organophosphorus Compounds / chemistry*
  • Phosphopeptides / chemistry
  • Phosphorylation
  • Porosity
  • Silicon Dioxide / chemistry*
  • Titanium / chemistry
  • Tyrosine / metabolism*

Substances

  • Epitopes
  • Organophosphorus Compounds
  • Phosphopeptides
  • titanium dioxide
  • Tyrosine
  • Silicon Dioxide
  • phenylphosphonic acid
  • Titanium