Data on the expression of SRPK1a in mammals

Metaxia Vlassi; Konstantinos A Kyritsis; Ioannis S Vizirianakis; Thomas Giannakouros; Michalis Aivaliotis; Eleni Nikolakaki

doi:10.1016/j.dib.2019.104210

Data on the expression of SRPK1a in mammals

Data Brief. 2019 Jul 3:25:104210. doi: 10.1016/j.dib.2019.104210. eCollection 2019 Aug.

Authors

Metaxia Vlassi¹, Konstantinos A Kyritsis², Ioannis S Vizirianakis², Thomas Giannakouros³, Michalis Aivaliotis^{4

5}, Eleni Nikolakaki³

Affiliations

¹ Institute of Biosciences & Applications, National Centre for Scientific Research "Demokritos", Athens, Greece.
² Laboratory of Pharmacology, Department of Pharmacy, Aristotelian University, Thessaloniki, Greece.
³ Laboratory of Biochemistry, Department of Chemistry, Aristotelian University, Thessaloniki, Greece.
⁴ Laboratory of Biological Chemistry, School of Medicine, Aristotelian University, Thessaloniki, Greece.
⁵ Functional Proteomics and Systems Biology (FunPATh)-Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Thessaloniki, Greece.

Abstract

SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains. We have previously reported the existence of a second less abundant isoform in humans, SRPK1a, which is formed from alternative splicing of the SRPK1 gene and contains an insertion of 171 amino acids at its N-terminal domain (Nikolakaki et al., 2001). In the NCBI database SRPK1a is annotated as a related to SRPK1-mRNA sequence coding for protein CAC39299.1. Here, we present data on the conservation of the extra sequence of SRPK1a in mammals. Furthermore, the retrieved sequences were comparatively analyzed and data on their evolutionary origin and relationships are also presented.

Keywords: Mammals; Phylogenetics; SR protein kinase; SRPK1; SRPK1a.