The role of Wnt signaling pathway in tumor metabolic reprogramming

Yongzhen Mo; Yumin Wang; Lishen Zhang; Liting Yang; Ming Zhou; Xiaoling Li; Yong Li; Guiyuan Li; Zhaoyang Zeng; Wei Xiong; Fang Xiong; Can Guo

doi:10.7150/jca.31166

The role of Wnt signaling pathway in tumor metabolic reprogramming

J Cancer. 2019 Jun 9;10(16):3789-3797. doi: 10.7150/jca.31166. eCollection 2019.

Authors

Yongzhen Mo^{1

2

3}, Yumin Wang^{1

2}, Lishen Zhang², Liting Yang¹, Ming Zhou^{1

2

3}, Xiaoling Li², Yong Li⁴, Guiyuan Li^{1

2

3}, Zhaoyang Zeng^{1

2

3}, Wei Xiong^{1

2

3}, Fang Xiong^{1

2

3}, Can Guo^{1

2

3}

Affiliations

¹ NHC Key Laboratory of Carcinogenesis, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
² The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha 410078, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

Abstract

The occurrence and development of tumors is a complex process involving long-term multi-factor participation. In this process, tumor cells from a set of abnormal metabolic patterns that are different from normal cells. This abnormal metabolic change is called metabolic reprogramming of tumors. Wnt signaling pathway is one of the critical signaling pathways regulating cell proliferation and differentiation. In recent years, it has been found that Wnt signaling participates in the occurrence and development of malignant tumors by affecting metabolic reprogramming. This paper reviews the role of Wnt signaling in tumor metabolic reprogramming to provide crucial theoretical guidance for targeted therapy and drug response of tumors.

Keywords: Wnt signaling; targeted therapy; tumor metabolic reprogramming.

Publication types

Review