T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils

Nazanin Samadi; Dominika Polak; Claudia Kitzmüller; Peter Steinberger; Gerhard J Zlabinger; Beatrice Jahn-Schmid; Barbara Bohle

doi:10.1002/eji.201848057

T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils

Eur J Immunol. 2019 Sep;49(9):1441-1443. doi: 10.1002/eji.201848057. Epub 2019 Aug 6.

Authors

Nazanin Samadi¹, Dominika Polak¹, Claudia Kitzmüller¹, Peter Steinberger², Gerhard J Zlabinger², Beatrice Jahn-Schmid¹, Barbara Bohle¹

Affiliations

¹ Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
² Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Abstract

Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils.

Keywords: Allergen-specific T cells; Allergy; Neutrophils; Th1; Th2.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Allergens / immunology
Antigen Presentation / immunology*
CD4-Positive T-Lymphocytes / immunology
CD58 Antigens / immunology
Cytokines / immunology*
HLA-DR Antigens / immunology
Humans
Lymphocyte Activation / immunology*
Neutrophils / immunology*
Th1 Cells / immunology*
Th2 Cells / immunology*

Substances

Allergens
CD58 Antigens
Cytokines
HLA-DR Antigens