Impaired cell surface expression and digestive function of sucrase-isomaltase gene variants are associated with reduced efficacy of low FODMAPs diet in patients with IBS-D

Gut. 2020 Aug;69(8):1538-1539. doi: 10.1136/gutjnl-2019-319411. Epub 2019 Jul 22.
No abstract available

Keywords: enzyme function; intestinal function; irritable bowel syndrome; low FODMAP diet; protein trafficking; sucrase-isomaltase gene variants.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COS Cells
  • Chlorocebus aethiops
  • Diet
  • Endoplasmic Reticulum / enzymology
  • Humans
  • Irritable Bowel Syndrome / diet therapy
  • Irritable Bowel Syndrome / enzymology*
  • Irritable Bowel Syndrome / genetics*
  • Isomaltose / analogs & derivatives
  • Isomaltose / metabolism
  • Membrane Proteins / metabolism*
  • Membrane Proteins / physiology
  • Mutation
  • Protein Transport / genetics
  • Sucrase-Isomaltase Complex / genetics*
  • Sucrase-Isomaltase Complex / metabolism*
  • Sucrase-Isomaltase Complex / physiology
  • Sucrose / metabolism

Substances

  • Membrane Proteins
  • Sucrose
  • Isomaltose
  • Sucrase-Isomaltase Complex
  • isomaltulose