A zebrafish tale of parabiosis, podocytes, and proteinuria

Brooke E Chambers; Rebecca A Wingert

doi:10.1016/j.kint.2019.04.041

A zebrafish tale of parabiosis, podocytes, and proteinuria

Kidney Int. 2019 Aug;96(2):272-275. doi: 10.1016/j.kint.2019.04.041.

Authors

Brooke E Chambers¹, Rebecca A Wingert²

Affiliations

¹ Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, University of Notre Dame, Notre Dame, Indiana, USA.
² Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, University of Notre Dame, Notre Dame, Indiana, USA. Electronic address: rwingert@nd.edu.

PMID: 31331464
DOI: 10.1016/j.kint.2019.04.041

Abstract

Glomerular damage is a harbinger of kidney dysfunction. Circulating permeability factors are implicated in causing primary and secondary damage to podocytes, leading to proteinuria and eventual progression to the nephrotic syndrome, but the mechanisms are not well understood. Müller-Deile et al. employed parabiosis with zebrafish embryos and found that a damaged glomerulus can impact a healthy one in a shared circulatory system. This methodology shows promise for elucidating kidney injury pathways in response to systemic disease.

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MeSH terms

Animals
Kidney Glomerulus
Parabiosis
Podocytes*
Proteinuria
Zebrafish