Calodioscurins A and B, two new isoprenylated xanthones from the stem bark of Calophyllum dioscurii P.F. Stevens

Abstract

Two new isoprenylated xanthones, calodioscurin A (1) and B (2) were isolated from the stem bark of Calophyllum dioscurii P.F. Stevens along with two known isoprenylated 4-phenylcoumarins, apetalolide (3) and methyl inophyllum P (4). The structures of two new compounds were determined based on their HRESIMS, IR, UV, 1D and 2D NMR spectral data. Compounds 1-4 were assayed on P-388 cells, compound 2 showed IC₅₀ value 11.5 μM and categorised moderate activity.

Keywords: Calodioscurins A and B; Calophyllum dioscurii; P-388 cell; isoprenylated xanthone.