Diverse functions of DNA glycosylases processing oxidative base lesions in brain

DNA Repair (Amst). 2019 Sep:81:102665. doi: 10.1016/j.dnarep.2019.102665. Epub 2019 Jul 8.

Abstract

Endogenous and exogenous oxidative agents continuously damage genomic DNA, with the brain being particularly vulnerable. Thus, preserving genomic integrity is key for brain health and neuronal function. Accumulation of DNA damage is one of the causative factors of ageing and increases the risk of a wide range of neurological disorders. Base excision repair is the major pathway for removal of oxidized bases in the genome and initiated by DNA glycosylases. Emerging evidence suggest that DNA glycosylases have non-canonical functions important for genome regulation. Understanding canonical and non-canonical functions of DNA glycosylases processing oxidative base lesions modulating brain function will be crucial for the development of novel therapeutic strategies.

Keywords: BER; Brain; DNA glycosylases; Neurodegeneration; Oxidative DNA damage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / enzymology*
  • Brain / metabolism
  • DNA / metabolism
  • DNA Damage*
  • DNA Glycosylases / metabolism*
  • DNA Repair*
  • Humans
  • Neurodegenerative Diseases / enzymology
  • Neurodegenerative Diseases / metabolism
  • Oxidation-Reduction
  • Oxidative Stress

Substances

  • DNA
  • DNA Glycosylases