Synthetic analogues of marine cytotoxic jaspine B and its stereoisomers

Miroslava Martinková; Jozef Gonda

doi:10.1016/j.carres.2019.06.016

Synthetic analogues of marine cytotoxic jaspine B and its stereoisomers

Carbohydr Res. 2019 Aug 1:482:107737. doi: 10.1016/j.carres.2019.06.016. Epub 2019 Jun 29.

Authors

Miroslava Martinková¹, Jozef Gonda²

Affiliations

¹ Institute of Chemical Sciences, Department of Organic Chemistry, P.J. Šafárik University, Moyzesova 11, 040 01, Košice, Slovak Republic. Electronic address: miroslava.martinkova@upjs.sk.
² Institute of Chemical Sciences, Department of Organic Chemistry, P.J. Šafárik University, Moyzesova 11, 040 01, Košice, Slovak Republic.

PMID: 31325781
DOI: 10.1016/j.carres.2019.06.016

Abstract

Synthetic analogues of the cytotoxic jaspine B and its stereochemical congeners have become an attractive target in the synthetic organic community owing to the search for novel therapeutic candidates with more potent anticancer activity, as cancer is the second leading cause of death worldwide. This review article provides insights into the different approaches and strategies available in the literature for the construction of jaspine B-related compounds.

Keywords: Cytotoxicity; Jaspine B; Jaspine B-Related analogues; SphK inhibitory activity; Stereoselective synthesis.

Publication types

Review

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Aquatic Organisms / chemistry*
Chemistry Techniques, Synthetic / methods*
Humans
Sphingosine / analogs & derivatives*
Sphingosine / chemical synthesis
Sphingosine / chemistry
Sphingosine / pharmacology
Stereoisomerism

Substances

Antineoplastic Agents
pachastrissamine
Sphingosine